منابع مشابه
Partial remission in new onset T1D New Definition for the Partial Remission Period in Children and Adolescents with T1D
1 Glostrup University Hospital, Department of Paediatrics, Glostrup, Denmark, 2 Department of Statistics, University of Southern Denmark, Denmark 3 Leicester Royal Infirmary Children’s Hospital, Leicester, United Kingdom 4 University of Ulm, Germany, 5 Trinity College , National Childrens Hospital, Dublin, Ireland 6 Ulleval University Hospital, Department of Pediatrics, Oslo, Norway 7 Clinique ...
متن کاملAvidity-Dependent Programming of Autoreactive T Cells in T1D
Fate determination for autoreactive T cells relies on a series of avidity-dependent interactions during T cell selection, represented by two general types of signals, one based on antigen expression and density during T cell development, and one based on genes that interpret the avidity of TCR interaction to guide developmental outcome. We used proinsulin-specific HLA class II tetramers to puri...
متن کاملVitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis
Background The vitamin D receptor (VDR) gene regulates insulin secretion from the pancreas and acts as a mediator of the immune response through vitamin D. Polymorphism in VDR causes alterations in the functioning of vitamin D, leading to type 1 diabetes (T1D) predisposition. The aim of the present study was to determine VDR gene polymorphism in association with T1D in Pakistanis. Methods The...
متن کاملDepression in adults in the T1D Exchange Clinic Registry.
OBJECTIVE Little is known about the frequency of depression in adults with type 1 diabetes (T1D) or its relationship to diabetes outcomes. The T1D Exchange clinic registry allowed us to explore depression in a large, heterogeneous sample. RESEARCH DESIGN AND METHODS Participants ≥18 years old (N = 6,172; median age 34 years; median diabetes duration 16 years; 55% female; and 89% non-Hispanic ...
متن کاملType 1 Diabetes and Autoimmunity
Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by the autoimmune response against pancreatic β cells. T1D is often complicated with other autoimmune diseases, and anti-islet autoantibodies precede the clinical onset of disease. The most common coexisting organ-specific autoimmune disease in patients with T1D is autoimmune thyroid disease, and its frequency is estimated at ...
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ژورنال
عنوان ژورنال: Current Opinion in Endocrinology & Diabetes and Obesity
سال: 2017
ISSN: 1752-296X
DOI: 10.1097/med.0000000000000348